Crystal structure of l-leucyl-l-isoleucine 2,2,2-tri­fluoro­ethanol monosolvate

Acta Crystallographica Section E: Crystallographic Communications

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[1]Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N-0315 Oslo, Norway

关键词: DIPEPTIDE;    HEAD-TO-TAIL CHAINS;    HYDROGEN BONDS;    LAYERED STRUCTURE;    CRYSTAL STRUCTURE;   

DOI  :  10.1107/S2056989016005302

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

Hydro­phobic dipeptides with either l-Leu or l-Phe constitute a rather heterogeneous group of crystal structures. Some form materials with large water-filled channels, but there is also a pronounced tendency to incorporate organic solvent mol­ecules, which then act as acceptors for one of the three H atoms of the charged N-terminal amino group. l-Leu-l-Ile has uniquely been obtained as two distinct hydrates, but has so far failed to co-crystallize with a simple alcohol. The present structure of C12H24N2O3·CF3CH2OH, which crystallizes with two dipeptide and two solvent mol­ecules in the asymmetric unit, demonstrates that when 2,2,2-tri­fluoro­ethanol is used as a solvent, its high capacity as a hydrogen-bond donor leads to formation of an alcohol solvate.

【 授权许可】

CC BY