Salutary effects of a novel oxidative stress modulator on adenine-induced chronic progressive tubulointerstitial nephropathy

American Journal of Translational Research

Susanne B Nicholas¹ 

关键词: Glutathione precursor;    oxidative stress modulator;    inflammation;    glutathione disulfide;    p-Iκ;    Bα;    NF-κ;    B;    NF-κ;    B p65;    hematocrit;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

BackgroundOxidative stress and inflammation promote the development and progression of chronic kidney disease. Oxidative stress is associated with depletion of tissue glutathione (GSH), the most abundant endogenous intracellular antioxidant, but degradation of oral GSH by digestive enzymes limits its therapeutic use. We hypothesized that GSH repletion with F1, a novel oral GSH precursor containing cystine as a cysteine carrier, would restore tissue GSH and attenuate oxidative stress and inflammation, and thereby reduce the severity of interstitial nephropathy in chronic renal failure (CRF).

【 授权许可】

CC BY-NC