ALK-immunoreactive neoplasms

International Journal of Clinical and Experimental Pathology

Parham Minoo¹ 

关键词: Anaplastic lymphoma kinase (ALK);    anaplastic large cell lymphoma (ALCL);    ALK-positive neoplasms;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

ContextSince the first discovery of anaplastic lymphoma kinase (ALK) in anaplastic large cell lymphoma (ALCL) by Morris et al in 1994, the number of ALK-positive neoplasms, either in the form of translocation or gain-of-function mutations, have been dramatically expanded from ALCL of T- and NK-cell origin, to diffuse large B-cell lymphoma, inflammatory myofibroblastic tumor (IMT), neuroblastoma, non-small cell lung carcinoma (NSCLC), undifferentiated anaplastic thyroid carcinoma, and rare type of sarcomas.

【 授权许可】

CC BY-NC