期刊论文详细信息
American Journal of Translational Research | |
Strategies to harness immunity against infectious pathogens after haploidentical stem cell transplantation | |
Sergio Rutella1  | |
关键词: Cytomegalovirus; adenovirus; Epstein-Barr virus; Aspergillus; Candida; immune reconstitution; stem cell transplantation; adoptive cell therapy; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
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【 摘 要 】
Viral and fungal infections account for significant morbidity and mortality, particularly in pediatric patients with profound immune suppression resulting from allogeneic hematopoietic stem cell transplantation (HSCT). Therapies with anti-viral and anti-fungal drugs are often associated with significant toxicity, are of limited efficacy and can induce drug resistance. One innovative approach to prevent and/or treat viral and fungal infections involves the adoptive transfer of in vitro-expanded or in vitro-generated pathogen-specific T cells. This review summarizes the clinical trials that have been run to date with virus- and fungus-specific T cells, with special emphasis on the clinical context of haploidentical HSCT for pediatric malignancies. It will also discuss initiatives and strategies to overcome the hurdles associated with time-consuming and complex GMP-grade laboratory procedures required to generate pathogen-specific T cells.【 授权许可】
CC BY-NC
【 预 览 】
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