The Role of Sphingomyelin Breakdown in Measles Virus Immunmodulation

Cellular Physiology and Biochemistry

关键词: Measles virus;    Immunosuppression;    T cell silencing;    Dendritic cell;    Sphingomyelinase;   

DOI  :  10.1159/000362981

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Measles virus (MV) efficiently causes generalized immunosuppression which accounts to a major extent for cases of measles-asscociated severe morbidity and mortality. MV infections alter many functions of antigen presenting cells (APC) (dendritic cells (DCs)) and lymphocytes, yet many molecular targets of the virus remain poorly defined. Cellular interactions and effector functions of DCs and lymphocytes are regulated by surface receptors. Associating with other proteins involved in cell signaling, receptors form part of receptosomes that respond to and transmit external signals through dynamic interctions with the cytoskeleton. Alterations in the composition and metabolism of membrane sphingolipids have a substantial impact on both processes. In this review we focus on the regulation of sphingomyelinase activity and ceramide release in cells exposed to MV and discuss the immunosuppressive role of sphingomyelin breakdown induced by MV.

【 授权许可】

CC BY-NC-ND