The estimation of comorbidities and serum concentration of cardiac biomarkers in patients with chronic obstructive pulmonary disease treated with invasive or nonivasive ventilation

Medicina Fluminensis

Pal, Sven¹  Šustić, Alan²  Knežević, Danijel²  Sotošek Tokmadžić, Vlatka²  Kuharić, Janja²  Harjač, Antonija³  Lainščak, Mitja⁴  Marčun, Robert⁴ 

[1] Dom zdravlja Primorsko-goranske županije, Rijeka;Katedra za anesteziologiju, reanimatologiju i intenzivno liječenje, Medicinski fakultet Sveučilišta u Rijeci, Rijeka;Opća bolnica Varaždin, Varaždin;Sveučilišna bolnica za plućne bolesti i alergije Golnik, Golnik, Slovenija

关键词: chronic obstructive pulmonary disease;    heart failure;    myocardial ischemia;    NT-proBNP;    troponin;   

DOI  :  

学科分类：医学（综合）

来源: Medicina Fluminensis

【 摘 要 】

Aim: To determine the most common comorbidities in patients with chronic obstructive pulmonary disease (COPD) treated with invasive or nonivasive ventilation, investigate serum concentration of cardiac biomarkers (N-terminal pro-brain natriuretic peptide or NT-proBNP and troponin) in these patients and analyze if type of ventilation affects serum concentrations of cardiac biomarkers. Patients and methods: We analyzed 41 medical records of patients with acute exacerbation of COPD treated with nonivasive or invasive ventilation in University hospital for pulmonary disease and alergies Golnik. Results: The most common comorbidities were arterial hypertension, chronic heart failure and ischemic heart disease. In COPD patients with acute exacerbation treated with nonivasive ventilation NT-proBNP levels were elevated in 23 (100 %) patient and troponin levels were elevated in 3 (14 %) patients. In COPD patients with acute exacerbation treated with invasive ventilation NT-proBNP levels were elevated in 17 (94 %) patients and troponin levels were elevated in 7 (39 %) patients. When comparing NT-proBNP and troponin levels between COPD patients with acute exacerbation treated with noninvasive ventilation and those treated with invasive ventilation the statistically significant difference was not found. Discussion and conclusion: Taking into consideration the common risk factors for development od COPD and cardiovascular diseases, in combination with anatomical and functional relation that exists between cardiovascular and pulmonary system, it is not unusual that this two conditions occur with high prevalence in the same patients. Because of the similar clinical manifestations it is important to actively search for these conditions in order to achieve optimal treatment for the patients.

【 授权许可】

CC BY