Antipsychotic Drugs And Salivary Leptin Levels In Wistar Rats

Current Health Sciences Journal

MARIA BOGDAN1¹ 

关键词: antipsychotics;    rats;    salivary leptin;    weight gain;   

DOI  :  10.12865/CHSJ.39.03.06

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Purpose. Mental dissorders such as psychosis, agitation, mania, dementia and bipolar disorder are treated with variable doses of antipsychotics. However, these drugs are often associated with metabolic side effects (weight gain), endocrine disruptions, diabetes mellitus and cardiovascular diseases.Unfortunately, a single reliable predictor of weight gain has not been found, but a relation is to be mentioned between the levels of circulating leptin, administration of antipsychotics and weight increase. The aim of this study was to assess the effects of exposure to antipsychotics from both generations on the salivary leptin levels. Material and Methods. Salivary leptin was determined by the ELISA technique, on three groups of male Wistar rats treated with haloperidole, haloperidole decanoate and aripiprazole for 4 weeks.Results. The present study evidences a significant statistical difference between the values of salivary leptin prior to and after the drug treatment with the first gener.

【 授权许可】

Unknown