Взаимосвязь особенностей аутоиммунного статуса у пациентов с катарактой на фоне псевдоэксфолиативного синдрома с развитием у них нарушений гидродинамики глаза

Oftal mokhirurgiya

Г. В. Сороколетов¹  С. А. Борзенок¹  М. З. Франковска-Герлак¹  А. Ю. Меньшиков¹  П. Е. Брижак² 

[1] ФГАУ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова» Минздрава России, Москва;ФГБУ «3 Центральный военный клинический госпиталь им. А.А. Вишневского» Минобороны России, Москва

关键词: pseudoexfoliation syndrome;    autoimmune profile;    hydrodynamic disturbances;    glaucoma;    псевдоэксфолиативный синдром;    аутоиммунный профиль;    гидродинамика глаза;    глаукома;   

DOI  :  10.25276/0235-4160-2016-2-10-15

学科分类：眼科学

来源: M H T K Mikrokhirurgiya Glaza

【 摘 要 】

Pseudoexfoliation syndrome (PEX) is the established trigger of glaucoma. The systemic character of PEX and the multifactor character of glaucoma can point to possible changes of the autoimmune profile of human body in the presence of this pathology and its possible link with hydrodynamic disturbances.Purpose.To study the peculiarities of the autoimmune serum profile in patients with cataract and PEX in the presence and absence of glaucoma.Material and methods.In the study there were examined 45 female patients aged 70-84 years with cataract and severe PEX. The patients were divided into 3 groups depending on the intensity of systemic cardio-vascular pathology and the presence or absence of glaucoma. Enzyme-linked immunosorbent assay was used to define the serum autoantibody level.Results.In examined groups it was detected the exceeding of the average statistical norm of the following serum autoantibodies: to the cytoplasm of neutrophilic granulocytes (ANCA), β1-adrenoreceptors and membrane antigen of trombocyte, which was the most pronounced one in the presence of systemic cardiovascular pathology and glaucoma process.Conclusions . The detected peculiarities of the autoimmune activity in patients with PEX can point to the significant role of the endothelial dysfunction in the development of glaucoma in such group of patients.

【 授权许可】

CC BY