Anticancer Activity of 2‐Amino‐substituted‐1,4‐naphthoquinone Derivatives in Ovarian Cancer Cells

Bulletin of the Korean Chemical Society

Cheolmin Jeon¹  Haneul Lee¹  Hye Choi¹  Sujeong Shin¹  Jung‐²  Umma Hafsa Preya² 

[1] Department of Chemical and Biological Engineering Hanbat National University Daejeon 34158 South Korea;Department of Life and Nanopharmaceutical Sciences and College of Pharmacy Kyung Hee University Seoul 02447 South Korea

关键词: 2‐;    Amino‐;    substituted‐;    1,4‐;    naphthoquinone derivatives;    Anticancer activity;    Ovarian cancer cells;   

DOI  :  10.1002/bkcs.11315

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

2‐Amino‐substituted‐1,4‐naphthoquinone derivatives (10–17) were synthesized from coupling reaction between 1,4‐dihydroxynaphthalene and amines in the presence of catalyst CeCl3.7H2O. Their anticancer activity was evaluated by using three ovarian cancer cells (A2780, SKOV3, and OVCAR3). Among the eight compounds, compound 13 containing metal chelating moiety had a relatively potent cytotoxic activity (IC50 < 10 μM) on all three ovarian cancer cells.

【 授权许可】

Unknown