Blood, Serum Glucose and Renal Parameters in Lead-Loaded Albino Rats and Treatment with Some Chelating Agents and Natural Oils

Turkish Journal of Biology

ABD EL RAHIEM A. ASHOUR¹ 

关键词: Lead acetate;    blood;    kidney;    albino rats;    therapy;    chelating agents;    natural oils;   

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

This study investigated lead impact on blood, serum glucose and kidney function and the efficacy of treatment with chelating agents meso-2,3-dimercaptosuccinic acid (DMSA), calcium disodium ethylenediaminetetraacetic acid (CaNa_2-EDTA) and natural olive and garlic oils to reduce lead toxicity in albino rats. Oral administration of 1000 or 2000 ppm lead acetate significantly decreased red blood cell count, hemoglobin level and hematocrit value at 20, 40 and 60 days compared with control groups (rats administered deionized water and 1000 or 2000 ppm sodium acetate). Serum glucose was also decreased significantly with both doses of lead acetate administration. In contrast, serum urea, uric acid and creatinine were significantly increased. Garlic or olive oils (1 ml/kg body weight/day, each) alleviated the previous changes in blood, serum glucose and renal parameters, whereas DMSA (50 mg/kg body weight/day) or CaNa_2-EDTA (100 mg/kg body weight/day) reversed such changes to near the control levels. Although chemical therapy is more efficient in reducing lead toxicity, natural products with their fewer side effects are still preferable.

【 授权许可】

Unknown