Ion Channels Involved in Cell Volume Regulation: Effects on Migration, Proliferation, and Programmed Cell Death in Non Adherent EAT Cells and Adherent ELA Cells

Cellular Physiology and Biochemistry

Else Kay Hoffmann¹ 

关键词: VRAC;    TMEM16;    TASK-2;    RVD;    Osmotic stress;    Cell migration;    Cell proliferation;    Programmed cell death;    Apoptosis;   

DOI  :  10.1159/000335843

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

This mini review outlines studies of cell volume regulation in two closely related mammalian cell lines nonadherent Ehrlich ascites tumour cells (EATC) and adherent Ehrlich Lettre ascites (ELA) cells. Focus is on the regulatory volume decrease (RVD) that occurs after cell swelling, the volume regulatory ion channels involved, and the mechanisms (cellular signalling pathways) that regulate these channels. Finally, I shall also briefly review current investigations in these two cell lines that focuses on how changes in cell volume can regulate cell functions such as cell migration, proliferation, and programmed cell death.

【 授权许可】

CC BY-NC-ND