Dexmedetomidine protects from post-myocardial ischaemia reperfusion lung damage in diabetic rats

Libyan journal of medicine

Gülay Kip¹ 

关键词: Diabetes Mellitus;    dexmedetomidine;    ischaemia reperfusion;    lung;   

DOI  :  10.3402/ljm.v10.27828

学科分类：医学（综合）

来源: Co-Action Publishing

【 摘 要 】

ObjectiveDiabetic complications and lipid peroxidation are known to have a close association. Lipid peroxidation commonly occurs at sites exposed to ischaemia, but distant organs and tissues also get damaged during ischaemia/reperfusion (I/R). Some of these targets are vital organs, such as the lung, liver, and kidney; the lung is the most frequently affected. The aim of our study was to investigate the effects of dexmedetomidine on I/R damage in lung tissue and on the oxidant/anti-oxidant system in diabetic rats.Material and methodsDiabetes was induced with streptozotocin (55 mg/kg) in 18 Wistar Albino rats, which were then randomly divided into three groups (diabetes control (DC), diabetes plus ischaemia-reperfusion (DIR), and diabetes plus dexmedetomidine-ischaemia/reperfusion (DIRD)) after the effects of diabetes were clearly evident. The rats underwent a left thoracotomy and then ischaemia was produced in the myocardium muscle by a left anterior descending artery ligation for 30 min in the DIR and DI...

【 授权许可】

CC BY