Estudio preliminar del tratamiento de úlceras crónicas con equivalentes cutáneos obtenidosporingeniería de tejidos

MEDISUR

Felipe Sojo¹  Francisco Antonio Arvelo Álvarez²  Pedro Pérez³  Carlos Cotte⁴ 

[1] Centro de Biociencias. Fundación Instituto de Estudios Avanzados. Hoyo de la Puerta. Valle de Sartenejas. Baruta. Estado Miranda. Caracas, Venezuela.;Fundacion Instituto de Estudios Avanzados. Venezuela.;Laboratorio de Cultivo de Tejidos y Biología de Tumores. Caracas, Venezuela.;Laboratorio de Cultivo de Tejidos y Biología de Tumores. Instituto de Biología Experimental. Caracas, Venezuela.

关键词: úlcera cutánea;    úlcera de la pierna;    terapéutica;    ingeniería de tejidos;    técnicas de cultivo de tejidos;   

DOI  :  

学科分类：医学（综合）

来源: Centro Provincial de Informacion de Ciencias Medicas de Cinfuegos

【 摘 要 】

Ulcers of the lower extremities have high prevalence and incidence. Their chronicity and frequent recurrences are two of their most important characteristics. Despite proper etiologic treatment and the great variety of dressings available, the healing rate and recovery speed remain low. Therefore, we conducted a study to obtain skin substitutes for clinical application by isolating and cultivating keratinocytes, which were seeded on a fibroblast-containing fibrin gel at high density. Hence, a new practical and inexpensive skin equivalent of straightforward and easy-to-perform transplantation was developed. Before starting the clinical trials to evaluate its advantages and applicability, we conducted a preliminary test to determine if the changes to the standard technique affected its feasibility and action. For this purpose, we implanted the new equivalents into six patients with chronic ulcers unresponsive to treatment. Outcomes in these patients showed that skin equivalents were feasible, effective, easy to handle and had rapid action on target tissues. All patients who completed the procedure recovered. An excellent example was a patient with a chronic lesion refractory to multiple conventional treatments that had been present for six months.

【 授权许可】

CC BY