Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-hy­droxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetra­deca­hydro-1H-cyclo­penta[a]phenanthren-17-yl]-N-meth­oxy-N-methyl­pro­pan­amide (Fernholz Weinreb amide)

Acta Crystallographica Section E: Crystallographic Communications

strand, O.A.H.¹  Haseeb, R.S.²  Viktorsson, E. ز  Ų  .² 

[1] Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N-0315 Oslo, Norway;School of Pharmacy, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway

关键词: CRYSTAL STRUCTURE;    LIVER X RECEPTOR;    OBESITY;    STEROID;   

DOI  :  10.1107/S2056989015001747

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

The literature compound 3β-hy­droxy-bis­nor-5-cholenic aldehyde is an important inter­mediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As part of our ongoing search for new LXR antagonists, the title compound, C24H39NO3, has proven to be an important inter­mediate in our new synthetic pathway, giving the corresponding aldehyde in high yield and in only three steps from the commercially available 3β-hy­droxy-bis­nor-5-cholenic acid. The title amide crystallized with two mol­ecules in the asymmetric unit, linked into helices by O—H⋯O hydrogen bonds involving the hy­droxy and carbonyl groups.

【 授权许可】

CC BY