Unique expression pattern of viral proteins in human herpesvirus 8-positive plasmablastic lymphoma: a case report

International Journal of Clinical and Experimental Pathology

Masatoshi Yamada¹ 

关键词: HHV-8-associated plasmablastic lymphoma;    large B-cell lymphoma arising in HHV8-associated multicentric Castleman’;    s disease;    HHV-8 latency-associated nuclear antigen 1;    open reading frame 59;    viral interleukin-6;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Background: Human herpesvirus 8 (HHV8)-positive plasmablastic lymphoma is a disease which correlates with acquired immunodeficiency syndrome (AIDS). Little is known about the pathogenesis of the disease due to its rarity. We report an autopsy case about AIDS related HHV-8-positive plasmablastic lymphoma and presents an examination about HHV8 related proteins for the disease by using immunohistochemical techniques. Case presentation: Two kinds of tumors complicated the male AIDS patient: one was HHV-8-positive plasmablastic lymphoma and the other was Kaposi’s sarcoma (KS). Immunohistochemically, the lymphoma cells were positive for HHV8-associated lytic early proteins as well as HHV8 latency-associated nuclear antigen 1 (LANA-1), and, on the other hand, the lymphoma cells were negative for lytic immediately early proteins. KS was positive for only LANA-1. Conclusion: These findings indicate that the lymphoma cells acquired an ability to proliferate without de novo HHV8 replication. Moreover, the onset mechanisms of HHV-8-positive plasmablastic lymphoma may be different from those of KS.

【 授权许可】

CC BY-NC