International Journal of Clinical and Experimental Pathology | |
Unique expression pattern of viral proteins in human herpesvirus 8-positive plasmablastic lymphoma: a case report | |
Masatoshi Yamada1  | |
关键词: HHV-8-associated plasmablastic lymphoma; large B-cell lymphoma arising in HHV8-associated multicentric Castleman’; s disease; HHV-8 latency-associated nuclear antigen 1; open reading frame 59; viral interleukin-6; | |
DOI : | |
学科分类:生理学与病理学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Background: Human herpesvirus 8 (HHV8)-positive plasmablastic lymphoma is a disease which correlates with acquired immunodeficiency syndrome (AIDS). Little is known about the pathogenesis of the disease due to its rarity. We report an autopsy case about AIDS related HHV-8-positive plasmablastic lymphoma and presents an examination about HHV8 related proteins for the disease by using immunohistochemical techniques. Case presentation: Two kinds of tumors complicated the male AIDS patient: one was HHV-8-positive plasmablastic lymphoma and the other was Kaposi’s sarcoma (KS). Immunohistochemically, the lymphoma cells were positive for HHV8-associated lytic early proteins as well as HHV8 latency-associated nuclear antigen 1 (LANA-1), and, on the other hand, the lymphoma cells were negative for lytic immediately early proteins. KS was positive for only LANA-1. Conclusion: These findings indicate that the lymphoma cells acquired an ability to proliferate without de novo HHV8 replication. Moreover, the onset mechanisms of HHV-8-positive plasmablastic lymphoma may be different from those of KS.
【 授权许可】
CC BY-NC
【 预 览 】
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RO201904032488122ZK.pdf | 723KB | download |