Sesamin Protects Against Cardiac Remodeling Via Sirt3/ROS Pathway

Cellular Physiology and Biochemistry

Qing-Qing Wu¹  Hai-Han Liao¹  Zheng Yang¹  Yuan Yuan¹  Qi-Zhu Tang¹  Wei Deng¹  Ning Zhang¹  Di Fan¹  Jian Ni¹  Fang-yuan Liu¹  Man Xu¹  Ya-Ge Jin¹ 

[1] a,b,c

关键词: Sesamin;    Sirtuin 3;    Cardiac hypertrophy;    Reactive oxygen species;    Mitogen-activated protein kinase;    Inflammation;   

DOI  :  10.1159/000486026

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Background/Aims Cardiac remodeling is associated with oxidative stress. Sesamin, a well-known antioxidant from sesamin seeds, have been used extensively as traditional health foods. However, there is little known about the effect of sesamin on cardiac remodeling. Therefore, the present study aimed to determine whether sesamin could protect against cardiac remodeling and to clarify potential molecular mechanisms. Methods The mice were subjected to either transverse aortic constriction (TAC) or sham surgery (control group). Beginning one week after surgery, the mice were oral gavage treated with sesamin (100mg·kg^-1·day^-1) or vehicle for 3 weeks. Cardiac hypertrophy was assessed by echocardiographic parameters, histological analyses and hypertrophic markers. Results Sesamin alleviated cardiac hypertrophy, inhibited fibrosis and attenuated the inflammatory response. The increased production of reactive oxygen species, the activation of ERK1/2-dependent nuclear factor-κB and the increased level of Smad2 phosphorylation were observed in cardiac remolding model that were treated with sesamin. Furthermore, TAC induced alteration of Sirt3 and SOD2 was normalized by sesamin treatment. Finally, a selective Sirt3 inhibitor 3-TYP blocks all the protective role of sesamin, suggesting that a Sirt3-dependent effect of sesamin on cardiac remodeling. Conclusion Sesamin improves cardiac function and prevents the development of cardiac hypertrophy via Sirt3/ROS pathway. Our results suggest the protective effect of sesamin on cardiac remolding.

【 授权许可】

CC BY-NC-ND