ФИЗИКО-ХИМИЧЕСКИЕ АСПЕКТЫ БИНАРНОЙ ТАМПОНАДЫ (ПФОС И СМ) ПОЛОСТИ СТЕКЛОВИДНОГО ТЕЛА

Oftal mokhirurgiya

Е. Г. Казимирова¹  П. В. Лыскин¹  А. М. Перепухов¹ 

[1] МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова, Москва

关键词: perfluorocarbon liquids;    silicone oil;    double tamponade;    retinal detachment;    перфторорганические соединения;    силиконовое масло;    бинарная тампонада;    отслойка сетчатки;   

DOI  :  10.25276/0235-4160-2014-1-64-67

学科分类：眼科学

来源: M H T K Mikrokhirurgiya Glaza

【 摘 要 】

Background. The authors previously developed a method of vitreous cavity double tamponade with perfluorocarbon liquid (PFCL) and silicone oil (SO) in retinal detachment surgery. There is a concern about safety of double tamponade based on the PFCL and silicone oil possible interaction.Purpose. To detect physical and chemical interaction of perfluorodecalin (PFD) and silicone oil after 30 days of their contact.Material and methods. The PFD and silicone oil were mixed together. Test tubes were put in thermostat with 37° C and kept for 30 days. After that both the PFD and silicone oil from the tubes were studied with the nuclear magnetic resonance (NMR) spectroscopy employing the Varian Inova 500W spectroscope. The NMR spectra19F,13Cand 1H were analyzed.Results. The19F,13Cand 1H spectrа of all the samples showed no new spikes meaning no new chemical substances were detected in the mixtures. According to the13Cspectrum, the PFD dissolves in silicone oil gradually, the longer PFD contacts with silicone oil the higher its concentration in the silicone oil. After 4 weeks of contact the silicone oil contained about 1% of PFD.Conclusion. The PFD and silicone oil interact with each other physically but not chemically. Thus, safety of double tamponade is not compromised by their interaction. .

【 授权许可】

CC BY