Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores

Cellular Physiology and Biochemistry

关键词: Mycobacteria;    Siderophore;    Biosynthesis;    Anti-tuberculosis;   

DOI  :  10.1159/000343343

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Iron is essential for nearly all biological events. Siderophores are indispensable for most organisms to obtain iron from iron-limiting milieus. This holds particularly true for pathogens such as the causative agent of tuberculosis – Mycobacterium tuberculosis. The categories of mycobacterial siderophores, their biosynthesis and regulation are summarized here. The siderophore biosynthesis and regulation differences between the pathogenic and non-pathogenic mycobacteria are highlighted from comparative genomic perspective, with an aim to find clues for drug or drug target within siderophore metabolism.

【 授权许可】

CC BY-NC-ND