Paracetamol poisoning in children

Medicina Fluminensis

Verbić, Arijan¹  Butorac Ahel, Ivona¹  Lah Tomulić, Kristina¹  Milardović, Ana¹ 

[1] Klinika za pedijatriju, KBC Rijeka, Rijeka

关键词: acetylcysteine;    children;    diagnosis;    paracetamol;    poisoning;    treatment;   

DOI  :  10.21860/medflum2016_4ver

学科分类：医学（综合）

来源: Medicina Fluminensis

【 摘 要 】

Paracetamol is the most commonly used antipyretic and analgesic in children and the association between paracetamol and hepatotoxicity has been well established. With it's widespread use, it became one of the most common pharmaceuticals associated with both unintentional and intentional poisoning and toxicity. Although therapeutic and unintentional overdosage typically occurs in children, hepatic damage or death due to paracetamol poisoning appears to be rare compared to adults. Despite this fact, paracetamol is currently a major and the most common identifiable cause of acute liver failure in children. Therefore, we bring this review article on well established modes of pathophysiologycal mechanisms of liver damage, current diagnostic and treatment concepts of acute paracetamol poisoning, and special overview of acetylcystein as cornerstone of therapy with proven safety and eficacy in children.

【 授权许可】

CC BY