期刊论文详细信息
Acta Crystallographica Section E: Crystallographic Communications | |
Crystal structures of five 6-mercaptopurine derivatives | |
Low, J.N.3  Gomes, L.R.4  Magalhã5  Borges, F.7  Cagide, F.8  es e Silva, D.1,13  | |
[1]CIQ/Departamento de Quι | |
[2]Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen AB24 3UE, Scotland | |
[3]ENAS– | |
[4]FP– | |
[5]Faculdade de Ciê | |
[6]REQUIMTE, Departamento de Quí | |
[7]de da UFP, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, P-4200-150 Porto, Portugal | |
[8]de, Escola Superior de Saú | |
[9]mica e Bioquí | |
[10]mica e Bioquι | |
[11]mica, Faculdade de Ciê | |
[12]ncias da Universidade do Porto, Rua do Campo Alegre, 687, P-4169-007, Porto, Portugal | |
[13]ncias de Saú | |
[14]ncias, Universidade do Porto, 4169-007 Porto, Portugal | |
关键词: CRYSTAL STRUCTURE; MERCAPTOPURINES; SUPRAMOLECULAR STRUCTURE; | |
DOI : 10.1107/S2056989016001833 | |
学科分类:数学(综合) | |
来源: International Union of Crystallography | |
【 摘 要 】
The crystal structures of five 6-mercaptopurine derivatives, viz. 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(3-methoxyphenyl)ethan-1-one (1), C16H14N4O3S, 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(4-methoxyphenyl)ethan-1-one (2), C16H14N4O3S, 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(4-chlorophenyl)ethan-1-one (3), C15H11ClN4O2S, 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(4-bromophenyl)ethan-1-one (4), C15H11BrN4O2S, and 1-(3-methoxyphenyl)-2-[(9H-purin-6-yl)sulfanyl]ethan-1-one (5), C14H12N4O2S. Compounds (2), (3) and (4) are isomorphous and accordingly their molecular and supramolecular structures are similar. An analysis of the dihedral angles between the purine and exocyclic phenyl rings show that the molecules of (1) and (5) are essentially planar but that in the case of the three isomorphous compounds (2), (3) and (4), these rings are twisted by a dihedral angle of approximately 38°. With the exception of (1) all molecules are linked by weak C—H⋯O hydrogen bonds in their crystals. There is π–π stacking in all compounds. A Cambridge Structural Database search revealed the existence of 11 deposited compounds containing the 1-phenyl-2-sulfanylethanone scaffold; of these, only eight have a cyclic ring as substituent, the majority of these being heterocycles.【 授权许可】
CC BY
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