Protective Effects of Bone Marrow-Derived Endothelial Progenitor Cells and Houttuynia Cordata in Lipopolysaccharide-Induced Acute Lung Injury in Rats

Cellular Physiology and Biochemistry

关键词: Houttuynia cordata;    ALI/ARDS;    ET-1;    Reactive oxygen species;    EPCs;   

DOI  :  10.1159/000356594

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Background/Aims Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a serious health problem, and an effective treatment is needed for use in the clinical setting. Methods In this study, we first constructed ALI models in Adult Sprague-Dawley rats. We then used an herbal medicine, Houttuynia cordata (HC), to enhance the effect of endothelial progenitor cells (EPCs) on ALI. Results (1) HC improved the therapeutic effects of EPCs on lipopolysachharide-induced ALI in the rat model; (2) HC down-regulated the anti-inflammatory response by suppressing inflammatory cytokines; (3) the combination of EPC and HC reduced expression of iNOS and ET-1 and subsequently prevented lung injury. Conclusion Combined EPC and HC therapy was more effective than either therapy alone. EPC and HC could be used in the clinical treatment of ALI.

【 授权许可】

CC BY-NC-ND