Cellular and molecular basis of cardiac regeneration

Turkish Journal of Biology

JUSTIN JUDD¹ 

关键词: Heart;    cardiac;    mammal;    vertebrate;    regeneration;   

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

Heart disease is one of the largest causes of death in humans throughout the developed world. Despite its critical role in maintaining physiologic homeostasis, the adult mammalian heart does not exhibit a significant capacity for regeneration. By contrast, several lower vertebrates exhibit a remarkable ability to regenerate the aging myocardium in response to severe injury. Additionally, recent evidence has shed light on a transient regenerative window in postnatal mammals. In this review, we discuss key findings that help to unravel the differences in cardiac regeneration across phylogeny and ontogeny. Furthermore, we highlight recent significant progress in the pursuit of adult mammalian cardiac regeneration. Collectively, this important body of work has great potential impact on human therapy for heart failure.

【 授权许可】

Unknown