Two ortho­rhom­bic polymorphs of hydro­morphone

Acta Crystallographica Section E: Crystallographic Communications

Hoffmann, M.¹  Mazurek, J.¹  Fernandez Casares, A.¹  Minardi, M.D.²  Sasine, J.²  Cox, D.P.³ 

[1] Crystallics B.V., Meibergdreef 31, 1105 AZ Amsterdam, The Netherlands;Noramco Inc., 1440 Olympic Drive, Athens, GA 30601, USA;Noramco Inc., 503 Carr Rd, Suite 200, Wilmington, DE 19809, USA

关键词: CRYSTAL STRUCTURE;    POLYMORPHISM;    HYDROMORPHONE,HYDROGEN BONDING;   

DOI  :  10.1107/S2056989016006563

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

Conditions to obtain two polymorphic forms by crystallization from solution were determined for the analgesic drug hydro­morphone [C17H19NO3; systematic name: (4R,4aR,7aR,12bS)-9-hy­droxy-3-methyl-1,2,4,4a,5,6,7a,13-octa­hydro-4,12-methano­benzofuro[3,2-e]iso­quinolin-7-one]. These two crystalline forms, designated as I and II, belong to the P212121 ortho­rhom­bic space group. In both polymorphs, the hydro­morphone mol­ecules adopt very similar conformations with some small differences observed only in the N-methyl amine part of the mol­ecule. The crystal structures of both polymorphs feature chains of mol­ecules connected by hydrogen bonds; however, in form I this inter­action occurs between the hydroxyl group and the tertiary amine N atom whereas in form II the hydroxyl group acts as a donor of a hydrogen bond to the O atom from the cyclic ether part.

【 授权许可】

CC BY