The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer

American Journal of Cancer Research

Jennifer Y Zhang¹ 

关键词: JNK;    skin cancer;    squamous cell carcinoma;    basal cell carcinoma;    cylindroma;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.

【 授权许可】

CC BY-NC