Association of IL-27 gene three polymorphisms with Crohn’s disease susceptibility in a Chinese Han population

International Journal of Clinical and Experimental Pathology

Zhengting Wang¹ 

关键词: IL-27;    polymorphism;    Crohn’;    s diseases;    susceptibility;    association study;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: To investigate the association of three polymorphisms in the Interleukin-27 (IL-27) gene with CD risk in Chinese population. Methods: This case-control study involved 312 CD patients and 479 age- and sex-matched healthy controls. Genotyping was performed using PCR-LDR method. Data were analyzed using Haplo. Stats program. Results: There were significant differences between patients and controls in allele distributions of rs153109 (Pallele = 0.036). The risk for CD associated with the rs153109-G mutant allele was increased by 26% (95% CI [confidence interval]: 1.02-1.56; P = 0.03) under the additive model and by 45% (95% CI: 1.07-1.97; P = 0.02) under the dominant model. In haplotype analysis, haplotype T-T-G (in order of rs17855750, rs181206 and rs153109) increased the odds of CD by 37% (95% CI: 1.04-1.81; P = 0.028). Conclusions: In conclusion, genetic defects in IL-27 gene showed remarkable associations with CD in Chinese.

【 授权许可】

CC BY-NC