Life and Death of Lymphocytes: A Volume Regulation Affair

Cellular Physiology and Biochemistry

关键词: Cell Volume Regulation;    Apoptotic Resistance;    Osmotic stress;    RVI;   

DOI  :  10.1159/000335864

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process.

【 授权许可】

CC BY-NC-ND