Crystal structure of vilazodone hydro­chloride methanol monosolvate

Acta Crystallographica Section E: Crystallographic Communications

Hu, X.-R.¹  Gu, J.-M.¹  Ye, J.-L.² 

[1] Chemistry Department, Zhejiang University, Hangzhou 310028, People's Republic of China;College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, People's Republic of China

关键词: CRYSTAL STRUCTURE;    BENZOFURAN;    INDOLE;    PIPERAZINE;    HYDROGEN BONDS;   

DOI  :  10.1107/S2056989016017734

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

In the title compound, C26H28N5O2+·Cl−·CH3OH {systematic name: 4-(2-carbamoyl-1-benzo­furan-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)but­yl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring plane is nearly perpendicular to the benzo­furan ring system, with a dihedral angle of 85.77 (2)°. In the crystal, the organic cations, Cl− anions and methanol solvent mol­ecules are linked by classical N—H⋯O and N—H⋯Cl hydrogen bonds, and weak C—H⋯O and C—H⋯π inter­actions into a three-dimensional supra­molecular architecture.

【 授权许可】

CC BY