The Clinical Implications of the Alpha 1- Antitrypsin Deficiency

Current Health Sciences Journal

F. PETRESCU1¹ 

关键词: alpha1-antitrypsin deficiency;    genotype;    morbidity;   

DOI  :  10.12865/CHSJ.39.03.02

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Alpha1-antitrypsin deficiency, one of the three most common potentially lethal genetic disorders among whites, an autosomal recessive genetic disease, leads to early-onset panacinar emphysema, increased lung cancer risk, chronic liver disease and skin disorders. It has recently been studied the causal relationship of alpha1-antitrypsin deficiency (mainly the Z allele) to inflammatory bowel disease, but also to the increased incidence of extraintestinal manifestation, the most frequent being the cutaneous, articular and hepatic ones, as well as its relation to fibromyalgia.

【 授权许可】

Unknown