Состояние нейроэндокринной регуляции и овариального резерва у ВИЧ-инфицированных женщин с репродуктивными нарушениями

Acta Biomedica Scientifica

Л. Ф. Шолохов¹  М. А. Даренская²  О. Я. Лещенко²  Е. В. Генич² 

[1] ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»;ФГБНУ «научный центр проблем здоровья семьи и репродукции человека»

关键词: ВИЧ-инфекция;    женщины;    репродуктивные нарушения;    нейроэндокринные расстройства;   

DOI  :  10.29413/ABS.2018-3.3.18

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Background: Among the subjects of the Russian Federation, Irkutsk region is an area with an unfavorable epidemiological situation for HIV-infection. Women living with HIV in Russia and visiting AIDS-centers represent a socially and economically active part of the population are at a young reproductive age and plan to have children. Aims: to study the state of the neuroendocrine system and the ovarian reserve in HIV-infected women with reproductive disorders. Materials and methods. We examined in 17 HIV-infected women with reproductive disorders and 33 women with HIV-infection and reproductive health at the age of 18-45 years (mean age 31,1 ± 4,4 years). The determination of hormone levels was carried out by a competitive solid-phase enzyme-linked immunosorbent assay. Results. The obtained results testify to neuroendocrine disorders in the form of a decrease in the level of total testosterone, 17-OH progesterone, dehydroepiandrosterone sulfate, as a manifestation of androgen deficiency of the body, as a result of ovarian dysfunction. Decrease in the level of Anti-Mullerian Hormone and increase the content of follicle-stimulating hormone, as a manifestation of the beginning of early menopause or a factor leading to infertility. Conclusions. The results of this study show that a woman's body on the background of HIV-infection reveals disorders of the neuroendocrine system dysfunction and decreased ovarian ovarian reserve, and as a result, reproductive disorders.

【 授权许可】

CC BY