Overview of C3 Glomerulopathy

Frontiers in Pediatrics

Vimal Master Sankar Raj¹ 

关键词: C3 glomerulopathies;    atypical HUS;    complement C3;    kidney disease;    children;   

DOI  :  10.3389/fped.2016.00045

学科分类：儿科学

来源: Frontiers

【 摘 要 】

C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway.

【 授权许可】

CC BY