Oral dexamethasone for the prevention of acute migraine recurrence in pediatric patients presenting to the emergency department with migraine: A pilot randomized controlled trial

Cephalalgia Reports

Serena LOrr¹ 

关键词: dexamethasone;    emergency department;    migraine recurrence;    pediatric migraine;    pilot trial;    r;    omized controlled trial;   

DOI  :  10.1177/2515816318804158

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objective:To assess the feasibility of a randomized controlled trial protocol that aims to determine the efficacy and safety of oral dexamethasone compared to placebo for the prevention of migraine recurrence in children and adolescents visiting the pediatric emergency department (ED) with migraine.Methods:This study was a two-arm, parallel-group, randomized, placebo-controlled, double-blind pilot trial of patients presenting to the pediatric ED with migraine. Eligible participants were randomized at 1:1 ratio to receive either oral dexamethasone 0.6 mg/kg (maximum 15 mg) or matched placebo as a single dose. Efficacy and safety outcomes were assessed at discharge, 48 h and 7 days after discharge. The primary outcome of the trial was feasibility and was assessed through participant recruitment rate, follow-up completion rates, participant satisfaction ratings and comparison of enrolled versus non-enrolled participants. Efficacy and safety outcomes were not analyzed given that this was a pilot study.Results...

【 授权许可】

CC BY