Stem and Progenitor Cell Therapy for Pulmonary Arterial Hypertension: Effects on the Right Ventricle (2013 Grover Conference Series):

Pulmonary Circulation

Arnoudvan der Laarse¹ 

关键词: pulmonary arterial hypertension;    right ventricular hypertrophy;    right ventricular failure;    cell therapy;    stem cells;    mesenchymal stem cells;    progenitor cells;    endothelial progenitor cells;    homing;    engraftment;    differentiation;    paracrine factors;   

DOI  :  10.1086/679701

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

In experimental animals and in patients with pulmonary arterial hypertension (PAH), a wide spectrum of structural and functional conditions is known that may be responsible for the switch of a state of “compensated” right ventricular (RV) hypertrophy to a state of RV failure. In recent years, therapy with differentiated cells, endothelial progenitor cells, and mesenchymal stem cells has been shown to cause partial or complete reversal of pathological characteristics of PAH. The therapeutic effects of stem or progenitor cell therapy are considered to be (1) paracrine effects from stem or progenitor cells that had engrafted in the myocardium (or elsewhere), by compounds that have anti-inflammatory, antiapoptotic, and proangiogenic actions and (2) unloading effects on the right ventricle due to stem or progenitor cell–induced decrease in pulmonary vascular resistance and decrease in pulmonary artery pressure.

【 授权许可】

CC BY