Potential Biomarkers in the Sera of Breast Cancer Patients from Bahawalpur, Pakistan:

Biomarkers in Cancer

Faiz-ul-HassanNasim¹ 

关键词: acute phase proteins (APPs);    biomarker;    breast cancer (BC);    haptoglobin (Hp);    inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4);    serum amyloid A (SAA);    transthyretin (TTR);    apolipoprotein A1 (apoA-1);   

DOI  :  10.4137/BIC.S10502

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Most of the approximately 90,000 cases of Breast Cancer (BC) documented annually in Pakistan are not diagnosed properly because of lack of suitable markers. We performed serum proteome expression profiling of BC and benign breast disease (BBD) patients with the aim to identify biomarkers that can be helpful for diagnosis and prognosis of the disease. Sera of patients were analyzed by one-dimensional SDS polyacrylamide gel electrophoresis (PAGE). Differentially expressed proteins were subjected to identification through LC-MS/MS analysis. In majority of the BC cases some acute phase proteins (APP) and some complement system components (C3 and C8) containing fractions were up-regulated with the exception of transthyretin (TTR) which was predominantly (68.75%) down-regulated (n = 33/48) in the sera of these patients. Varying expression patterns were observed in BBD patients and healthy controls. These differentially expressed proteins have the potential to serve as diagnostic biomarkers for BC as well as benign breast diseases.

【 授权许可】

CC BY