The effects of advanced glycation end products (AGEs) on dermal wound healing and scar formation: a systematic review:

Scars, Burns & Healing

LennertVan Putte¹ 

关键词: Advanced glycosylation end products (AGEs);    skin ageing;    photoageing;    dermal wound healing;    scarring;    cicatrix;    connective tissue;    fibrosis;   

DOI  :  10.1177/2059513116676828

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Introduction:With ageing, the skin gradually loses its youthful appearance and functions like wound healing and scar formation. The pathophysiological theory of Advanced Glycation End products (AGEs) has gained traction during the last decade. This review aims to document the influence of AGEs on the mechanical and physiologic properties of the skin, how they affect dermal wound healing and scar formation in high-AGE populations like elderly patients and diabetics, and potential therapeutic strategies.Methods:This systematic literature study involved a structured search in Pubmed and Web of Science with qualitative analysis of 14 articles after a three-staged selection process with the use of in- and exclusion criteria.Results:Overall, AGEs cause shortened, thinned, and disorganized collagen fibrils, consequently reducing elasticity and skin/scar thickness with increased contraction and delayed wound closure. Documented therapeutic strategies include dietary AGE restriction, sRAGE decoy receptors, aminogu...

【 授权许可】

CC BY