Ankylosing Spondylitis Patients Have Impaired Osteoclast Gene Expression in Circulating Osteoclast Precursors

Frontiers in Medicine

Inês P. Perpétuo¹ 

关键词: monocytes;    osteoclasts;    ankylosing spondylitis;    CSF1R;    RANK;    NFATc1;    gene expression;    humans;   

DOI  :  10.3389/fmed.2017.00005

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

IntroductionAnkylosing spondylitis (AS) is typically characterized by focal bone overgrowth and also by systemic bone loss. We hypothesize that the increased osteoproliferation found in AS might be partially due to reduced ability of osteoclast precursors (OCPs) to differentiate into osteoclasts (OCs). Therefore, our aim was to characterize bone remodeling and pro-osteoclastogenesis inflammatory environment, monocytes’ phenotype, and in vitro osteoclast differentiation in AS patients.

【 授权许可】

CC BY