Hypergravity As a Tool for Cell Stimulation: Implications in Biomedicine

Frontiers in Astronomy and Space Sciences

Grillone, Agostina¹  Ciofani, Gianni²  Marino, Attilio²  Mattoli, Virgilio³  Genchi, Giada G.³  Rocca, Antonella³ 

[1] Anna, Pisa, Italy;BioRobotics Institute, Scuola Superiore Sant'Center for Micro-BioRobotics @SSSA, Istituto Italiano di Tecnologia, Pisa, Italy

关键词: Hypergravity;    Nervous System;    Musculoskeletal System;    Immune System;    Tissue Engineering;   

DOI  :  10.3389/fspas.2016.00026

学科分类：空间科学

来源: Frontiers

【 摘 要 】

Gravity deeply influences numerous biological events in living organisms. Variations in gravity values induce adaptive reactions that have been shown to play important roles, for instance in cell survival, growth, and spatial organization. In this paper, we summarize effects of gravity values higher than that one experienced by cells and tissues on Earth, i.e., hypergravity, with particular attention to the nervous and the musculoskeletal systems. Besides the biological consequences that hypergravity induces in the living matter, we will discuss the possibility of exploiting this augmented force in tissue engineering and regenerative medicine, and thus hypergravity significance as a new therapeutic approach both in vitro and in vivo.

【 授权许可】

CC BY