Seroprevalence Survey of Visceral Leishmaniasis among Children up to 12 Years old and Domestic Dogs in Rural Areas of Dehloran District, Ilam Province of West Part of Iran, 2014

Shahid Beheshti University of Medical Sciences

Hooshang Khazan¹  Behnaz Akhoundi²  Belal Armand⁴  Mohammad Gorgipour⁵  Eznollah Azargashsb⁷  Bahram Kazemi⁷  Mehdi Mohebali⁷  Sasan Khazaei⁸ 

[1] Mycology, Jahrom University of Medical Sciences;Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences and Department of Medical Parasitology &Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Mycology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Iran;Mycology, School of Public Health and Institute of Public Health Research, and Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Iran;Department of Biotechnology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Medical Parasitology &Department of Parasitology and Mycology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Social Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

关键词: Visceral Leishmaniasis;    Direct Agglutination Test;    Human;    Dog;    Iran;   

DOI  :  10.22037/nbm.v5i2.13047

学科分类：生物科学（综合）

来源: Shahid Beheshti University of Medical Sciences

【 摘 要 】

Background: Visceral leishmaniasis (VL), caused by Leishmania infantum (L. infantum), is a life-threatening vector-borne parasitic disease is distributed in some parts of the world. The disease is endemic in some parts of Iran. This study was aimed to determine the seroprevalence of VL among children and domestic dogs (as a reservoir of the parasite) in Dehloran, west of Iran. Materials and Methods:This cross-sectional study was carried out in Dehloran County. The blood samples of 872 children up to 12 years old and 52 dogs were collected from 10 villages of Dehloran using randomly-clustered sampling method. Sera were separated from all peripheral blood samples and tested by direct agglutination test (DAT). Anti- Leishmania infantumantibodies at titers of ≥1:800 and ≥1:80 were considered asLeishmania infantuminfection in human and dog, respectively. Results:In general, among 872 human samples, 1.03% of samples had anti- Leishmaniaantibody with 1:1600 titers and 1.26% had 1:800 titers. In addition, from 52 dog samples, 21.15% of dogs had a titer of ≥1:320 and 25% had 1:80 and 1:160 titers. Conclusion:Our findings indicate that the seropositive dogs in the studied areas are considerable andL. infantummay be circulated between human and domestic dog in the studied area. Further study of isolation and molecular identification ofLeishmaniaspp. is recommended.

【 授权许可】

CC BY