LTβR expression on hematopoietic cells regulates acute inflammation and influences maturation of myeloid subpopulations:

Innate Immunity

Anja KWege¹ 

关键词: Bone marrow chimera;    dampening inflammation;    DSS-induced colitis;    LTβR;    MDSC;   

DOI  :  10.1177/1753425913497242

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Lymphotoxin beta-receptor (LTβR) is involved in the formation and maintenance of secondary lymphoid structures, as well as in the regulation of inflammatory responses. Because LTβR lymphoid structure formation continues to develop in infants, we compared two different chimera models: one using adult mice and the other using a transplantation model of neonatal mice. To elucidate the function of LTβR on lymphoid and non-lymphoid cells, we generated bone marrow chimeras on the wild type C57Bl/6 and the LTβR-deficient (LTβR−/−) background, and reconstituted the mice with bone marrow cells reciprocally. These chimeric mice were analyzed in the experimental model of acute dextran sulfate sodium-induced colitis. Interestingly, both models revealed not only equal reconstitution levels but also similar immunological responses: LTβR expression on stromal cells is essential for lymph node formation, whereas LTBR on hematopoietic cells is crucial for a decrease in inflammation. In addition, mice lacking LTβR on hemat...

【 授权许可】

CC BY