Elevated peripheral blood lymphocyte-to-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma

Cancer Communications

Dong-Hua Luo¹  Zhong-Han Yang¹  Lin Wang¹  Xiu-Yu Cai²  Rui Sun²  Ming-Yuan Chen²  Xing Lu²  Pei-Yu Huang³  Wei-Xiong Xia⁴  Xiong Zou⁴  Qiu-Yan Chen⁵  Yue Yan⁶  Ling Guo⁷  Yan-Qun Xiang⁷  Hai-Qiang Mai⁷  Rou Jiang⁷ 

[1] Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China;State Key Laboratory of Oncology in South China;Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, P. R. China;Department of Cancer Prevention, Guangzhou, P. R. China;Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China;Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China;Sun Yat-sen University Cancer Center

关键词: Metastatic nasopharyngeal carcinoma;    Lymphocyte count;    Monocyte count;    Lymphocyte-to-monocyte ratio;    Overall survival;    Prognosis;   

DOI  :  10.1186/s40880-015-0025-7

学科分类：肿瘤学

来源: Springer

【 摘 要 】

Patients with metastatic nasopharyngeal carcinoma (NPC) have variable survival outcomes. We have previously shown that an elevated peripheral blood lymphocyte-to-monocyte ratio (LMR) is associated with an increased metastatic risk in patients with primary NPC. The present study aimed to investigate the prognostic value of pretreatment LMR in a large cohort of metastatic NPC patients. Clinical data of 672 patients with metastatic NPC diagnosed between January 2003 and December 2009 were analyzed. The peripheral lymphocyte and monocyte counts were retrieved, and LMR was calculated. Receiver operating characteristic (ROC) curve analysis and univariate and multivariate COX proportional hazards analyses were performed to evaluate the association of LMR with overall survival (OS). Univariate analysis revealed that an elevated absolute lymphocyte count (≥1.390 × 109/L) and LMR (≥2.475) as well as a decreased monocyte count (<0.665 × 109/L) were significantly associated with prolonged OS. Multivariate Cox proportional hazard analysis showed that LMR (hazard ratio [HR] = 0.50, 95 % confidence interval [CI] = 0.41–0.60, P < 0.001), absolute lymphocyte count (HR = 0.77, 95 % CI = 0.64–0.93, P = 0.007), and monocyte count (HR = 1.98, 95 % CI = 1.63–2.41, P < 0.001) were independent prognostic factors. By stratification analyses, only LMR remained a significant predictor of prognosis. We identified pretreatment LMR as an independent prognostic factor for patients with metastatic NPC. Independent validation of our findings is needed.

【 授权许可】

CC BY