Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway

Frontiers in Medicine

Erica Carolina¹ 

关键词: endothelial progenitor cells;    glucocorticoids;    CXCR4;    wound healing;    prostaglandin E2;    HIF2α;   

DOI  :  10.3389/fmed.2018.00276

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Background: Endothelial progenitor cells (EPCs) can be used to treat ischemic disease in cell-based therapy owing to their neovascularization potential. Glucocorticoids (GCs) have been widely used as strong anti-inflammatory reagents. However, despite their beneficial effects, side effects, such as impairing wound healing are commonly reported with GC-based therapy, and the effects of GC therapy on the wound healing function of EPCs are unclear.

【 授权许可】

CC BY