Feeding the Infant at High-Risk of Celiac Disease – An Update

Frontiers in Pediatrics

Robert N. Lopez¹ 

关键词: children infants;    celiac disease;    HLA genes;    breast feeding;    gluten;   

DOI  :  10.3389/fped.2015.00047

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Celiac disease is a life-long condition with significant morbidity and health-care costs (1). Conventional understanding of etiopathological factors, specifically the roles played by the HLA genes (DQ2 and DQ8), has greatly advanced in recent years. Furthermore, it is now well accepted that these HLA genes contribute to an increased risk of celiac disease for first-degree relatives of those affected by the condition. One such group is infants born to a mother with known celiac disease. Current guidelines for such high-risk infants include the recommendation to introduce gluten between 4 and 6 months of age and ideally, while still breastfeeding. Emerging data from a number of large studies refute the basis for these recommendations, thereby necessitating a new approach.

【 授权许可】

CC BY