Racial Differences in Blood Lipids Lead to Underestimation of Cardiovascular Risk in Black Women in a Nested Observational Study:

Global Advances in Health and Medicine

Mark S.Mcintosh¹ 

关键词: Women;    metabolic syndrome;    triglycerides;    cholesterol;    race;    cardiovascular disease;   

DOI  :  10.7453/gahmj.2012.076

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:During screening for enrollment in a clinical trial, we noticed potential racial disparities in metabolic syndrome variables in women who responded to our study advertisement. We designed a nested observational study to investigate whether metabolic syndrome variables differed between non-Hispanic blacks and non-Hispanic whites.Methods:The cohort comprised of women who have met the preliminary clinical trial criteria (body mass index [BMI] 25—45, age 20—75 years, and no use of lipid-lowering medications or supplements). These women, including 116 blacks and 138 whites, provided fasting blood samples for analysis of serum lipid profile.Results:Blacks had lower mean triglycerides (81.1 ± 3.3 mg/dL vs 140.6 ± 5.9 mg/dL; P < .0001), total cholesterol (176.1 ± 3.6 mg/dL vs 201.6 ± 3.3 mg/dL; P < .0001), and low-density lipoprotein (111.7 ± 3.3 mg/dL vs 128.2 ± 2.9 mg/dL; P < .001) and higher mean BMI (37.2 ± 0.5 vs 35.2 ± 0.5; P < .01) and diastolic blood pressure (82.4 ± 0.8 mmHg vs 79.4 ± 0.7 mmHg...

【 授权许可】

CC BY