Diagnostic and therapeutic applications of tumor‐associated exosomes

Precision Radiation Oncology

Ning Wang¹  Li Xie² 

[1] School of Medicine and Life Sciences University of Jinan, Shandong Academy of Medical Sciences Jinan Shandong Province China;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Cancer Hospital Affiliated to Shandong University Jinan Shandong Province China

关键词: Exosomes;    tumor;    biomarker;    therapy;   

DOI  :  10.1002/pro6.13

学科分类：医学（综合）

来源: Wiley

【 摘 要 】

Exosomes are nanometric membrane vesicles released by almost all cell types. Their contents vary, and can include functional miRNA, mRNA, proteins, and lipids wrapped in a double layer of lipid membranes. Tumor‐derived exosomes interact with the tumor microenvironment, and are involved in tumor initiation, angiogenesis, invasion, and metastasis. Exosomes have abundant tumor‐specific molecules, with the potential to become new biomarkers for tumor diagnosis. Furthermore, an increasing number of studies use exosomes or their modified products as cell‐free vaccines and drug delivery carriers in oncotherapy. The present review focuses on the progress of exosomes in tumor diagnosis and therapies.

【 授权许可】

CC BY-NC-ND