Alpha Particles Induce Autophagy in Multiple Myeloma Cells

Frontiers in Medicine

Jean-Baptiste Gorin¹ 

关键词: bismuth-213;    multiple myeloma;    radiobiology;    autophagy;    immunogenicity;    ionizing radiation;   

DOI  :  10.3389/fmed.2015.00074

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

ObjectivesRadiation emitted by the radionuclides in radioimmunotherapy (RIT) approaches induce direct killing of the targeted cells as well as indirect killing through the bystander effect. Our research group is dedicated to the development of α-RIT, i.e., RIT using α-particles especially for the treatment of multiple myeloma (MM). γ-irradiation and β-irradiation have been shown to trigger apoptosis in tumor cells. Cell death mode induced by 213Bi α-irradiation appears more controversial. We therefore decided to investigate the effects of 213Bi on MM cell radiobiology, notably cell death mechanisms as well as tumor cell immunogenicity after irradiation.

【 授权许可】

CC BY