Evaluation of the safety and satisfaction of rheumatic patients with accelerated infliximab infusion

Advances in Rheumatology

lio Freire de Carvalho¹  Jozé²  Joyce Meyre Vieira de Oliveira²  Andrea Nogueira S. Lanty Silva²  Roberto Paulo Correia de Araujo²  Maria Natividade Pereira dos Santos² 

[1] Institute of Health Sciences, Universidade Federal da Bahia (Federal University of Bahia), Salvador, Brazil;SOS Vida, Rheumatology Unit, Salvador, Brazil

关键词: Infliximab;    Infusion;    Immunobiologics;    Rheumatoid arthritis;    Ankylosing spondylitis;    Psoriatic arthritis;    Spondyloarthritis;   

DOI  :  10.1186/s42358-018-0016-x

学科分类：过敏症与临床免疫学

来源: Springer

【 摘 要 】

Infliximab infusion generally occurs in 2–4 h. Recent studies have suggested the possibility of accelerated infusion (1 h) of this drug. To evaluate the safety of accelerated infliximab infusion in patients with rheumatic diseases. In addition, patient satisfaction was also assessed. A prospective, single-center, non-randomized study with 34 patients with rheumatic diseases was conducted from July to November 2016. Patients with the following were excluded: history of allergic reaction to biologics, asthma or severe atopy. All patients previously received a 2- to 3-h infliximab infusion. The infusion rate was accelerated to 1 h, and premedication was excluded. The infusion was monitored in all patients. A total of 34 patients were included in the study [rheumatoid arthritis (n = 16), ankylosing spondylitis (n = 15), psoriatic arthritis (n = 2) and enteropathic arthropathy (n = 1)], with an average age of 48.7 ± 18.6 years; 55.5% of the patients were female, and 29.4% were white. The duration of disease was 9.5 ± 9.2 years, and the duration of infliximab use was 38.9 ± 27.6 months, with a mean dose per infusion of 414.2 ± 158.1 (range, 200–800) mg. The mean infliximab infusion time prior to the study was 2.2 ± 0.4 h. A total of 6 (17.6%) patients received premedication. The premedication was suspended. There were no adverse effects during or after infusion. Ninety-seven percent of the patients and 100% of the health workers were satisfied with the accelerated infusion. Our data support the safe use of accelerated infliximab infusion in rheumatic patients, with high satisfaction among patients and health workers.

【 授权许可】

CC BY