PLoS One | |
Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents | |
Sudipta Basu1 Sohan Patil1 Vineetha Mandlik2 Shailza Singh2 Ramanamurthy Bopanna2 | |
[1] Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, Pashan, Pune, India;National Centre for Cell Science, NCCS Complex, SP Pune University Campus, Ganeshkhind, Pune, India | |
关键词: Promastigotes; Coumarins; Apoptosis; Macrophages; Mitochondria; Nanoparticles; Cytotoxicity; Leishmaniasis; | |
DOI : 10.1371/journal.pone.0164585 | |
学科分类:医学(综合) | |
来源: Public Library of Science | |
【 摘 要 】
Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary therapeutic agents in addition to the current treatment modalities. In this study, we have performed an in-silico screening of the coumarin derivatives and their anti-leishmanial properties has been explored both in-vitro and in-vivo. One of the compounds (compound 2) exhibited leishmanicidal activity and to further study its properties, nanoliposomal formulation of the compound was developed. Treatment of cutaneous lesions in BALB/c mice with compound 2 showed significantly reduced lesion size as compared to the untreated mice (p<0.05) suggesting that compound 2 may possess anti-leishmanial properties.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201904027556198ZK.pdf | 3117KB | download |