Antiulcer Effect of Extract/Fractions of Eruca sativa: Attenuation of Urease Activity

Journal of Evidence-Based Integrative Medicine

HaroonKhan¹ 

关键词: Eruca sativa;    extract/fractions;    urease inhibition;   

DOI  :  10.1177/2156587214527452

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Eruca sativa (Rocket salad) is known for its antiulcer properties in the traditional system of treatment. The present study was, therefore, designed to scrutinize its effect on urease activity in vitro. The results demonstrated marked attenuation of urease by the crude extract of various test concentrations with IC50 value of 7.77 mg/mL. On fractionation, marked change in inhibitory profile was observed. The ethyl acetate fraction was the most potent urease inhibitor with IC50 value of 4.17 mg/mL followed by the aqueous fraction with an IC50 value of 5.83 mg/mL. However, hexane did not show significant urease inhibition. In conclusion, the present study illustrated strong antagonism of urease activity and thus validated scientifically the traditional use of the plant in the treatment of ulcers.

【 授权许可】

CC BY-NC