Perspectives of aging study on stem cell

Biomedical Dermatology

Sang-Hun Bae¹  Jisook Moon¹  Pierre Leblanc²  Kwang-Soo Kim²  Chun-Hyung Kim³ 

[1] Department of biotechnology, College of Life Science, CHA University, Seoul, South Korea;Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, USA;Paean Biotechnology, Daejeon, South Korea

关键词: Aging;    Stem cell;    OMICS technology;    Target therapy;   

DOI  :  10.1186/s41702-017-0007-2

学科分类：皮肤病学

来源: Springer

【 摘 要 】

Aging is the result of a complex polygenetic trait characterized by decreased regeneration capacity and increased vulnerability to external and internal perturbations. Consequently, the inevitable process critically influences longevity, health, and disease susceptibility, ultimately leading to age-related pathologies and death. Gaining insights into inherent properties of aging and identifying definitive biomarkers and/or signatures are prerequisites for a better understanding and for the design of therapeutics for a wide range of age-related diseases that would improve the quality of life of the elderlies. However, a comprehensive understanding of the molecular mechanisms underlying aging has been hampered by its complex nature. Although the process has been subjected to substantial data-driven analyses including genomics, transcriptomics, and proteomics in a systemic manner, aging’s complexity hampers proper analysis as well as interpretation of the resulting outputs. Therefore, we review recent consequences focused on stem cell aging and age-related diseases.

【 授权许可】

CC BY