Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients:

Chronic Stress

Chadi G.Abdallah¹ 

关键词: connectivity;    depression;    global brain connectivity;    ketamine;    lanicemine;    rapid-acting antidepressants;   

DOI  :  10.1177/2470547018796102

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

BackgroundIdentifying the neural correlates of ketamine treatment may facilitate and expedite the development of novel, robust, and safe rapid-acting antidepressants. Prefrontal cortex (PFC) global brain connectivity with global signal regression (GBCr) was recently identified as a putative biomarker of major depressive disorder. Accumulating evidence have repeatedly shown reduced PFC GBCr in major depressive disorder, an abnormality that appears to normalize following ketamine treatment.MethodsFifty-six unmedicated participants with major depressive disorder were randomized to intravenous placebo (normal saline; n = 18), ketamine (0.5 mg/kg; n = 19), or lanicemine (100 mg; n = 19). PFC GBCr was computed using time series from functional magnetic resonance imaging scans that were completed at baseline, during infusion, and at 24-h posttreatment.ResultsCompared to placebo, ketamine significantly increased average PFC GBCr during infusion (p = 0.01) and at 24-h posttreatment (p = 0.02). Lanicemine had no si...

【 授权许可】

CC BY