Полиморфизм -141с Ins/ Del гена D 2 -дофаминергического рецептора как маркер раннего развития эссенциальной артериальной гипертензии у подростков

Acta Biomedica Scientifica

Л. И. Колесникова¹  В. М. Поляков²  Т. А. Баирова²  А. С. Косовцева²  Л. В. Рычкова² 

[1] ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»;ФГБНУ «научный центр проблем здоровья семьи и репродукции человека»

关键词: подростки;    эссенциальная артериальная гипертензия;    психология;    вегетативный статус;   

DOI  :  10.29413/ABS.2018-3.3.17

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Background. The relevance of the search for genetic markers of essential hypertension (EH), is beyond doubt. The importance of research of dopaminergic system genes consists primarily of pleiotropic effects of dopamine on different systems and functions of the body. The aim of this study was to identify the association of polymorphism -141C 1/D D2-dopaminergic receptor (DRD2) with parameters of psycho-vegetative status and cardiovascular system indicators in adolescents with EH. Methods. We carried out an investigation of 14-17-year old (15.92 ± 1.12) Caucasian male patients with EH (n = 110) in clinic of Scientific Centre for Family Health and Human Reproduction Problems. Psychological testing, clinoorthostatic test, ambulatory blood pressure monitoring (ABPM), and genotyping have been carried. Results. 11-genotype is associated with higher «hypomania» personality traits (scale 9 of Mini-SMIL was 4.2 (4-5) in carriers of the 11-genotype and 4.0 (3-4) in 1D and DD-genotype carriers, p = 0.024), asthenosympathicotonic variant of autonomic support and pressure load (ejection fraction in carriers of the 11-genotype was 71.47 ± 5.98 % and 68.44 ± 6.01 % in 1D and DD-genotype carriers, p = 0.044, time of systolic blood pressure hypertension in carriers of the 11-genotype - 35.50 (20.5-51.5) and 18.30 (6.5-32) - in 1D and DD-genotype carriers, p = 0.010, the time of diastolic blood pressure hypertension in 11-genotype carriers was 13 (7.85-26.5) and 2 (0.9-11) - in 1D and DD-genotype carriers, p = 0,002). Conclusion. -141C I/D DRD2 polymorphism is associated with disorders of important indicators of psycho-vegetative status and cardiovascular system, including circadian organization of blood pressure, which allows considering it as a marker of early development of EH in adolescents.

【 授权许可】

CC BY